AG Neuromodulation psychischer Erkrankungen

Ziel der Arbeitsgruppe ist es, die Effektivität neuromodulatorischer Therapien zur Behandlung von psychischen Erkrankungen zu erforschen und zu optimieren. Im Fokus stehen die tiefe Hirnstimulation und die transkranielle Magnetstimulation. Wir beschäftigen uns mit den Veränderungen neuronaler Netzwerke bei dem Tourette-Syndrom und der Zwangsstörung. Zusätzlich führen wir grundlagenwissenschaftliche Studien durch, um neue Erkenntnisse über unser Gehirn und unser Verhalten im gesunden als auch im erkrankten Zustand zu gewinnen. Hierzu nutzen wir neben den genannten neuromodulatorischen Techniken auch elektrophysiologische und bildgebende Verfahren.

Projekte

  • Charakterisierung neuronaler Netzwerke der Tic-Entstehung und Unterdrückung
    Sonderforschungsbereich 1451: Schlüsselmechanismen physiologischer und krankheitsbedingt gestörter motorischer Kontrolle
    Sprecher: Gereon R. Fink
    Teilprojektleiter: Juan Carlos Baldermann, Veerle Visser-Vandewalle
  • Kortikale Modulation durch thalamische Tiefe Hirnstimulation bei Patienten mit Tourette-Syndrom
    Köln Fortune
    Projektleiter: Thomas Schüller
Kooperationen

  • Klinik für Stereotaxie und funktionelle Neurochirurgie, Uniklinik Köln, Prof. Dr. Veerle Visser-Vandewalle
  • Klinik und Poliklinik für Neurologie, Uniklinik Köln, Prof. Dr. Michael Barbe
  • Universität zu Köln, Humanwissenschaftliche Fakultät, Kognitive Neuropsychologie, Prof. Dr. Simone Vossel
  • Otto-von-Guericke-Universität, Fakultät für Naturwissenschaften, Institut für Psychologie II, Prof. Dr. Markus Ullsperger
  • Medizinische Hochschule Hannover, Klinik für Psychiatrie, Prof. Dr. Kirsten Müller-Vahl
  • University of Florida, Department of Neurology, Prof. Dr. Michael Okun
Publikationen

2021

Baldermann, J. C.Kuhn, J.Schüller, T.Kohl, S., Andrade, P., Schleyken, S., ... & Huys, D. (2021). Thalamic deep brain stimulation for Tourette Syndrome: A naturalistic trial with brief randomized, double-blinded sham-controlled periods. Brain Stimulation

Schüller, T., Gruendler, T. O., Smith, E. E., Baldermann, J. C.Kohl, S., Fischer, A. G., ... & Huys, D. (2021). Performance monitoring in obsessive-compulsive disorder: insights from internal capsule/nucleus accumbens deep brain stimulation. NeuroImage: Clinical, 102746

Schüller, C. B., Wagner, B. J., Schüller, T.Baldermann, J. C.Huys, D., Kerner auch Koerner, J., ... & Kuhn, J. (2021). Temporal discounting in adolescents and adults with Tourette syndrome. Plos one, 16(6), e0253620

2020

Smith, E. E., Schüller, T.Huys, D.Baldermann, J. C., Ullsperger, M., Allen, J. J., ... & Gruendler, T. O. (2020). Prefrontal delta oscillations during deep brain stimulation predict treatment success in patients with obsessive-compulsive disorder. Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation, 13(1), 259-261

Schleyken S, Baldermann JC, Huys D, Visser-Vandewalle V, Kuhn J, Kohl S. Deep brain stimulation and sensorimotor gating in Tourette syndrome and Obsessive-Compulsive Disorder. Journal of Psychiatric Research 2020

Smith EE, Schüller T, Huys D, Baldermann JC, Andrade P, Allen J, Visser-Vandewalle V; Ullsperger M; Gruendler T; Kuhn J. A brief demonstration of frontostriatal connectivity in OCD patients with intracranial electrodes. Neuroimage. 2020;220:117138.

Andrade P, Heiden P, Hoevels M, Baldermann JC, Huys D, Visser-Vandewalle V.  Modulation of Fibers to Motor Cortex during Thalamic DBS in Tourette Patients Correlates with Tic Reduction. Brain Sci. 2020

Johnson KA, Duffley G, Anderson DN, Ostrem JL, Welter ML, Baldermann JC, Kuhn J, Huys D, Visser-Vandewalle V, Foltynie T, Zrinzo L, Hariz M, Leentjens AFG, Mogilner AY, Pourfar MH, Almeida L, Gunduz A, Foote KD, Okun MS, Butson CR. Structural connectivity predicts clinical outcomes of deep brain stimulation for Tourette syndrome. Brain. 2020

Schüller T, Fischer A, Gründler T, Huys D, Baldermann JC, Ullsperger M, Kuhn J. Decreased Transfer of Value to Action in Tourette Syndrome. Cortex, Volume 126, 2020

Wu H, Hariz M, Visser-Vandewalle V, Zrinzo L, Coenen VA, Sheth SA, Bervoets C, Naesström M, Blomstedt P, Coyne T, Hamani C, Slavin K, Krauss JK, Kahl KG, Taira T, Zhang C, Sun B, Toda H, Schlaepfer T, Chang JW, Régis J, Schuurman R, Schulder M, Doshi P, Mosley P, Poologaindran A, Lázaro-Muñoz G, Pepper J, Schechtmann G, Fytagoridis A, Huys D, Gonçalves-Ferreira A, D'Haese PF, Neimat J, Broggi G, Vilela-Filho O, Voges J, Alkhani A, Nakajima T, Richieri R, Djurfeldt D, Fontaine P, Martinez-Alvarez R, Okamura Y, Chandler J, Watanabe K, Barcia JA, Reneses B, Lozano A, Gabriëls L, De Salles A, Halpern CH, Matthews K, Fins JJ, Nuttin B. Deep brain stimulation for refractory obsessive-compulsive disorder (OCD): emerging or established therapy? Mol Psychiatry. 2020 Nov 3. doi: 10.1038/s41380-020-00933-x

Li N, Baldermann JC, Kibleur A, Treu S, Akram H, Elias GJB, Boutet A, Lozano AM, Al-Fatly B, Strange B, Barcia JA, Zrinzo L, Joyce E, Chabardes S, Visser-Vandewalle V, Polosan M, Kuhn J, Kühn AA, Horn A. A unified connectomic target for deep brain stimulation in obsessive-compulsive disorder. Nat Commun. 2020 Jul 3;11(1):3364. doi: 10.1038/s41467-020-16734-3.

Kuhn J, Baldermann JC. Elucidating neural network changes induced by deep brain stimulation for OCD. Brain. 2020;143(5):1293-1296. doi: 10.1093/brain/awaa108. PMID: 32438409

Andrade P, Heiden P, Hoevels M, Schlamann M, Baldermann JC, Huys D, Visser-Vandewalle V. Modulation of Fibers to Motor Cortex during Thalamic DBS in Tourette Patients Correlates with Tic Reduction. Brain Sci. 2020 May 15;10(5):302. doi: 10.3390/brainsci10050302.

Beyler M, Kuhn J. Pathologisches Glücksspielen. Fortschr Neurol Psychiatr .2020 Apr;88(4):230-231. doi: 10.1055/a-1109-0717. Epub 2020 Apr 23.

Ueberberg B, Frommberger U, Messer T, Zwanzger P, Kuhn J, Anghelescu I, Ackermann K, Assion HJ. Drug-Induced Liver Injury (DILI) in Patients with Depression Treated with Antidepressants: A Retrospective Multicenter Study. Pharmacopsychiatry. 2020 Mar;53(2):60-64. doi: 10.1055/a-1071-8028. Epub 2020 Jan 20. PMID: 31958850.

Dürschmid S, Reichert C, Kuhn J, Freund HJ, Hinrichs H, Heinze HJ. Deep brain stimulation of the nucleus basalis of Meynert attenuates early EEG components associated with defective sensory gating in patients with Alzheimer disease - a two-case study. Eur J Neurosci. 2020 Mar;51(5):1201-1209. doi: 10.1111/ejn.13749. Epub 2017 Nov 22. PMID: 29055119.

Bonnet U, Specka M, Soyka M, Alberti T, Bender S, Grigoleit T, Hermle L, Hilger J, Hillemacher T, Kuhlmann T, Kuhn J, Luckhaus C, Lüdecke C, Reimer J, Schneider U, Schroeder W, Stuppe M, Wiesbeck GA, Wodarz N, McAnally H, Scherbaum N. Ranking the Harm of Psychoactive Drugs Including Prescription Analgesics to Users and Others-A Perspective of German Addiction Medicine Experts. Front Psychiatry. 2020 Oct 26;11:592199. doi: 10.3389/fpsyt.2020.592199. PMID: 33192740; PMCID: PMC7649209.

2019

Baldermann, J. C., Bohn, K. P., Hammes, J., Schüller, C. B., Visser-Vandewalle, V., Drzezga, A., & Kuhn, J. (2019). Local and Global Changes in Brain Metabolism during Deep Brain Stimulation for Obsessive-Compulsive Disorder. Brain sciences, 9(9), 220. DOI:10.3390/brainsci9090220 (IF:2.786)

Baldermann, J. C., Hahn, L., Dembek, T. A., Kohl, S., Kuhn, J., Visser-Vandewalle, V., ... & Huys, D. (2019). Weight Change after Striatal/Capsule Deep Brain Stimulation Relates to Connectivity to the Bed Nucleus of the Stria Terminalis and Hypothalamus. Brain Sciences, 9(10), 264. DOI:10.3390/brainsci9100264 (IF:2.786)

Baldermann, J. C., Melzer, C., Zapf, A., Kohl, S., Timmermann, L., Tittgemeyer, M., Huys D., ... & Kuhn, J. (2019). Connectivity profile predictive of effective deep brain stimulation in obsessive-compulsive disorder. Biological psychiatry, 85(9), 735-743. DOI:10.1016/j.biopsych.2018.12.019 (IF:11.501)

Bullinger, M., Kuhn, J., Leopold, K., Janetzky, W., & Wietfeld, R. (2019). Quality of life as a target criterion in schizophrenia therapy. Fortschritte der Neurologie-Psychiatrie, 87(6), 348-356. DOI:10.1055/a-0646-3951 (IF:0.635)

Huys, D., Kohl, S., Baldermann, J. C., Timmermann, L., Sturm, V., Visser-Vandewalle, V., & Kuhn, J. (2019). Open-label trial of anterior limb of internal capsule–nucleus accumbens deep brain stimulation for obsessive-compulsive disorder: insights gained. Journal of Neurology, Neurosurgery & Psychiatry, 90(7), 805-812. DOI:10.1136/jnnp-2018 (IF:8.327)

Johnson, K. A., Fletcher, P. T., Servello, D., Bona, A., Porta, M., Ostrem, J. L., ..., Baldermann, J.C., Kuhn, J., Huys, D., … & Butson, C. R. (2019). Image-based analysis and long-term clinical outcomes of deep brain stimulation for Tourette syndrome: a multisite study. Journal of Neurology, Neurosurgery & Psychiatry, 90(10), 1078-1090. DOI: 10.1136/jnnp-2019-320379 (IF:8.327)

Knudsen, K., Krack, P., Tonder, L., Houeto, J. L., Rau, J., Schade-Brittinger, C., ..., Kuhn, J., … & Kühn, A. (2019). Programming parameters of subthalamic deep brain stimulators in Parkinson's disease from a controlled trial. Parkinsonism & related disorders, 65, 217-223. DOI: 10.1016/j.parkreldis.2019.05.023 (IF: 4.36)

Kohl, S., Hannah, R., Rocchi, L., Nord, C. L., Rothwell, J., & Voon, V. (2019). Cortical paired associative stimulation influences response inhibition: cortico-cortical and cortico-subcortical networks. Biological psychiatry, 85(4), 355-363. DOI:10.1016/j.biopsych.2018.03.009 (IF:11.501)

Kuhn, J., Baldermann, J. C., & Huys, D. (2019). Dysregulation of the Reward and Learning Systems in Tourette Syndrome. JAMA Neurology, 76(9), 1124-1124. DOI:10.1001/jamaneurol.2019.2027 (IF:12.321)

Kuhn, J., & Huys, D. (2019). Tic-Disorder-A Disease between Neurology and Psychiatry. Fortschritte der Neurologie-Psychiatrie, 87(10), 538. DOI: 10.1055/a-0963-1419 (IF: 0.635)

Reimer, J., Kuhn, J., Wietfeld, R., Janetzky, W., & Leopold, K. (2019). Motivational interviewing. Der Nervenarzt, 90(11), 1144-1153. DOI:10.1007/s00115-019-0702-x (IF: 0.829)

Schreiber, J., & Kuhn, J. (2019). Tiergestützte Therapie. Fortschritte der Neurologie Psychiatrie, 87(05), 282-283. DOI:10.1055/a-0878-2573 (IF:0.635)

Schüller, C. B., Kuhn, J., Jessen, F., & Hu, X. (2019). Neuronal correlates of delay discounting in healthy subjects and its implication for addiction: an ALE meta-analysis study. The American journal of drug and alcohol abuse, 45(1), 51-66. DOI:10.1080/00952990.2018.1557675 (IF:2.767)

2018

Kohl S, Baldermann JC. (2018) Progress and challenges in deep brain stimulation for obsessive-compulsive disorder. Pharmacol Ther. 2018 Jun;186:168-175. doi: 10.1016/j.pharmthera.2018.01.011. Epub 2018

Kohl S, Hannah R, Rocchi L, Nord CL, Rothwell J, Voon V.(2018) Cortical Paired Associative Stimulation Influences Response Inhibition: Cortico-cortical and Cortico-subcortical Networks.

Biol Psychiatry. 2019 Feb 15;85(4):355-363. doi: 10.1016/j.biopsych.2018.03.009. Epub 2018 Apr 3.

Voon V, Droux F, Chabardes S, Bougerol T, Kohl S, David O, Krack P, Polosan M. (2018) Dissociable Effects of Subthalamic Stimulation in Obsessive Compulsive Disorder on Risky Reward and Loss Prospects.Neuroscience. 2018 Jul 1;382:105-114. doi: 10.1016/j.neuroscience.2018.03.010. Epub 2018

Gescher DM, Kahl KG, Hillemacher T, Frieling H, Kuhn J, Frodl T. (2018) Epigenetics in Personality Disorders: Today's Insights. Front Psychiatry 19; 9:579.

Schüller T, Gruendler TOJ, Huster R, Baldermann JC, Huys D, Ullsperger M, Kuhn J. (2018) Altered electrophysiological correlates of motor inhibition and performance monitoring in Tourette's syndrome. Clin Neurophysiol;129(9):1866-1872.

Lhommée E, Wojtecki L, Czernecki V, Witt K, Maier F, Tonder L, Timmermann L, Hälbig TD, Pineau F, Durif F, Witjas T, Pinsker M, Mehdorn M, Sixel-Döring F, Kupsch A, Krüger R, Elben S, Chabardès S, Thobois S, Brefel-Courbon C, Ory-Magne F, Regis JM, Maltête D, Sauvaget A, Rau J, Schnitzler A, Schüpbach M, Schade-Brittinger C, Deuschl G, Houeto JL, Krack P (2018) Behavioural outcomes of subthalamic stimulation and medical therapy versus medical therapy alone for Parkinson's disease with early motor complications (EARLYSTIM trial): secondary analysis of an open-label randomised trial.; EARLYSTIM study group. Lancet Neurol.17(3):223-231

Peisker CB, Schüller T, Peters J, Wagner BJ, Schilbach L, Müller UJ, Visser-Vandewalle V, Kuhn J. (2018) Nucleus Accumbens Deep Brain Stimulation in Patients with Substance Use Disorders and Delay Discounting. Brain Sci. 2018 Jan 27;8(2).

Martinez-Ramirez D, Jimenez-Shahed J, Leckman JF, Porta M, Servello D, Meng FG, Kuhn J, Huys D, Baldermann JC, Foltynie T, Hariz MI, Joyce EM, Zrinzo L, Kefalopoulou Z, Silburn P, Coyne T, Mogilner AY, Pourfar MH, Khandhar SM, Auyeung M, Ostrem JL, Visser-Vandewalle V, Welter ML, Mallet L, Karachi C, Houeto JL, Klassen BT, Ackermans L, Kaido T, Temel Y, Gross RE, Walker HC, Lozano AM, Walter BL, Mari Z, Anderson WS, Changizi BK, Moro E, Zauber SE, Schrock LE, Zhang JG, Hu W, Rizer K, Monari EH, Foote KD, Malaty IA, Deeb W, Gunduz A, Okun MS. (2018) Efficacy and Safety of Deep Brain Stimulation in Tourette Syndrome: The International Tourette Syndrome Deep Brain Stimulation Public Database and Registry. JAMA Neurol. 2018 Mar 1;75(3):353-359.

Bullinger M, Kuhn J, Leopold K, Janetzky W, Wietfeld R. (2018) [Quality of life as a target criterion in schizophrenia therapy]. Fortschr Neurol Psychiatr. 2018 Dec 12.

Bodatsch M, Kuhn J. (2018) Anti-NMAR-Enzephalitis — Mimikry der schizophrenen Erstmanifestation. Fortschr Neurol Psychiatr. 2018 Feb;86(2):125-134. doi: 10.1055/s-0043-122143.

Kuhn J, Gaebel W. (2018) Schwerpunktheft EKT. Fortschr Neurol Psychiatr. 2018 Nov;86(11):678-679

Kudling R, Hartmut Schoels W, Kuhn J.(2018) Tako-Tsubo Cardiomyopathy during a series of Electroconvulsive Therapy (ECT) applications: A case report, systematic literature research and discussion of specific risk factors.Fortschr Neurol Psychiatr. 2018 Nov;86(11):699-710.

2017

Hartfiel, C., Bodatsch, M., Klosterkoetter, J., & Kuhn, J. (2017). Establishment of an Animal Based Therapy at a University Hospital for Psychiatry: Results of a Preliminary Study and Future Prospects. Psychiatrische Praxis, 44(1), 36-40.

Hashemiyoon, R., Kuhn, J., & Visser-Vandewalle, V. (2017). Putting the pieces together in Gilles de la Tourette syndrome: exploring the link between clinical observations and the biological basis of dysfunction. Brain topography, 30(1), 3-29.

Kuhn, J. (2017). Eine Option beim schweren Tourette-Syndrom?. InFo Neurologie & Psychiatrie, 19(11), 11-11.

Kohl, S., & Kuhn, J. (2017). Deep Brain Stimulation for Obsessive-Compulsive Disorder. Jama, 318(4), 392-392.

Merkl A, Austa S, Schneider GH, Visser-Vandewalle V, Horn A, Kühn AA, Kuhn J, Bajbouj M. Deep Brain Stimulation of the Subcallosal Cingulate Gyrus in Patients with Treatment-Resistant Depression: a double-blinded randomized controlled study and long-term follow-up in eight patients. Journal of Affective Disorders 2017; 227, 521-529.

2016

Baldermann, J. C., Kohl, S., Visser-Vandewalle, V., Klehr, M., Huys, D., & Kuhn, J. (2016). Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum Reproducibly Improves Symptoms of Body Dysmorphic Disorder. Brain Stimulation, 9(6), 957-959.

Baldermann, J. C., Schueller, T., Huys, D., Becker, I., Timmermann, L., Jessen, F., et al. (2016). Deep Brain Stimulation for Tourette-Syndrome: A Systematic Review and Meta-Analysis. Brain Stimulation, 9(2), 296-304.

Bodatsch, M., & Kuhn, J. (2016). Alienation: Differential Psychopathology of Ego-Disturbances. Fortschritte Der Neurologie Psychiatrie, 84(11), 699-707.

Deeb, W., Rossi, P. J., Porta, M., Visser-Vandewalle, V., Servello, D., Silburn, P., et al. (2016). The International Deep Brain Stimulation Registry and Database for Gilles de la Tourette Syndrome: How Does It Work? Frontiers in Neuroscience, 10.

Hardenacke, K., Hashemiyoon, R., Visser-Vandewalle, V., Zapf, A., Freund, H. J., Sturm, V., et al. (2016). Deep Brain Stimulation of the Nucleus Basalis of Meynert in Alzheimer's Dementia: Potential Predictors of Cognitive Change and Results of a Long-Term Follow-Up in Eight Patients. Brain Stimulation, 9(5), 799-800.

Holle, J. F., Jessen, F., & Kuhn, J. (2016). Clinical Phenomenology of Autoimmune Encephalitis. Fortschritte Der Neurologie Psychiatrie, 84(5), 271-280.

Huys, D., Bartsch, C., Koester, P., Lenartz, D., Maarouf, M., Daumann, J., et al. (2016). Motor Improvement and Emotional Stabilization in Patients With Tourette Syndrome After Deep Brain Stimulation of the Ventral Anterior and Ventrolateral Motor Part of the Thalamus. Biological Psychiatry, 79(5), 392-401.

Kohl, S., Baldermann, J. C., Denys, D., & Kuhn, J. (2016). A Synergistic Treatment Strategy for Severe Obsessive Compulsive Disorder. Neuromodulation, 19(5), 542-544.

Kohl, S., Baldermann, J. C., & Kuhn, J. (2016). The bed nucleus: a future hot spot in obsessive compulsive disorder research? Molecular Psychiatry, 21(8), 990-991.

Maarouf, M., Neudorfer, C., El Majdoub, F., Lenartz, D., Kuhn, J., & Sturm, V. (2016). Deep Brain Stimulation of Medial Dorsal and Ventral Anterior Nucleus of the Thalamus in OCD: A Retrospective Case Series. Plos One, 11(8).

Maier, F., Lewis, C. J., Horstkoetter, N., Eggers, C., Dembek, T. A., Visser-Vandewalle, V., et al. (2016). Subjective perceived outcome of subthalamic deep brain stimulation in Parkinson's disease one year after surgery. Parkinsonism & Related Disorders, 24, 41-47.

Merkl, A., Neumann, W. J., Huebl, J., Aust, S., Horn, A., Krauss, J. K., et al. (2016). Modulation of Beta-Band Activity in the Subgenual Anterior Cingulate Cortex during Emotional Empathy in Treatment-Resistant Depression. Cerebral Cortex, 26(6), 2626-2638.

2015

Lewis, C. J., Maier, F., Horstkötter, N., Zywczok, A., Witt, K., Eggers, C., Meyer, T. D., Dembek, T. A., Maarouf, M., Moro, E., Zurowski, M., Woopen, C., Kuhn, J., Timmermann, L. (2015). Subjectively perceived personality and mood changes associated with subthalamic stimulation in patients with Parkinson's disease. Psychol Med., 45(1), 73-85.

Luigjes, J., van den Brink, W., Schuurman, R., Kuhn, J., Denys, D. (2015). Is deep brain stimulation a treatment option for addiction? Addiction, 110(4), 547-548.

Kuhn, J., Hardenacke, K., Lenartz, D., Gründler, T. O. J., Ullsperger, M., Bartsch, C., Mai, J. K., Zilles, K., Bauer, A., Matusch, A., Schulz, R. J., Noreik, M., Bührle Maintz, D., Woopen, C., Häussermann, P., Hellmich, M., Klosterkötter, J., Wiltfang, J., Maarouf,  M., Freund, H. J., Sturm, V. (2015) Deep brain stimulation of the nucleus basalis Meynert in Alzheimer’s dementia: results from a Phase I study (MEYND-DBS). Mol Psych 20(3), 353-60.

Schrock, L. E., Mink, J. W., Woods, D. W., Porta, M., Servello, D., Visser-Vandevalle, V., Silburn, P. A., Foltynie, T., Walker, H. C., Shahed-Jimenez, J., Savica, R., Klassen, B. T., Machado, A. G., Foote, K. D., Zhang, J.-G., Hu, W., Ackermans, L., Temel, Y., Mari, Z., Changizi, B. K., Lozano, A., Ay, M., Kaido, T., Agid, Y., Welter, M. L., Khandhar, S. M., Mogilner, A. G., Pourfar, M. H., Walter, B. L., Juncos, J. L., Kuhn, J.,  Leckman, J. F., Neimat, J. A., Okun, M. S., Tourette Syndrome Association, Inc. Tourette Syndrome (2015) Deep Brain Stimulation: A Review and Updated Recommendations. Mov Disord 30(4), 448-471.

Schüller, T., Gruendler, T. O. J., Jocham, G., Klein, T., Timmermann, L., Visser-Vandewalle, V., Kuhn, J., Ullsperger, M. (2015) Rapid feedback processing in human nucleus accumbens and motoric thalamus. Neuropsychologia 70, 246-254.

Kohl, S., Ebbert, L., Sartorius, A., Kuhn, J. (2015) A step forward in elucidating the mystery of OCD. Eur Arch Psychiatry Clin Neurosci 265, 735-736.

Kuhn, J., Hardenacke, K., Shubina, E., Lenartz, D., Visser-Vandewalle, V., Zilles, K., Sturm, V., Freund, H. J. (2015) Deep brain stimulation of the nucleus basalis of Meynert in early stage of Alzheimer's Dementia. Brain Stim 8, 838-839.

Noreik, M., Kuhn, J., Hardenacke, K., Lenartz, D., Bartsch, C., Bauer, A., Bührle, C. P., Häussermann, P., Hellmich, M., Klosterkötter, J., Wiltfang, J., Maarouf,  M., Freund, H.-J., Visser-Vandewalle, V., Sturm, V., Schulz, R.-J. (2015) Changes in nutritional status after deep brain stimulation of the nucleus basalis of Meynert in Alzheimer’s disease – Results of a phase I study. J Nutr Health Aging 19, 812-818.

Kohl, S., Aggeli, K., Foltynie, T., Limousin, P., Zrinzo, L., Hariz, M., Kuhn, J., Jahanshahi, M. (2015) Effects of GPi stimulation on motor inhibition in Parkinson’s disease. J Neurol 262, 1741-1750.

Alonso, P., Cuadras, D., Gabriëls, L., Denys, D., Greenberg, B. D., Jiménez-Ponce, F., Kuhn, J., Lenartz, D., Mallet, L., Nuttin, N., Real, E., Segalas, C., Menchón, J. M. (2015)  Deep brain stimulation for Obsessive-Compulsive Disorder: A meta-analysis of treatment outcome and predictors of response. Plos One Jul 24;10(7):e0133591.

Kohl, S., Gruendler, T. O. J., Huys, D., Shubina, E., Dembek, T., Hellmich, M., Blum, M., Timmermann, L., Ahmari, S., Klosterkötter, J., Sturm, V., Visser-Vandewalle, V., Kuhn, J. (2015) Effects of Deep Brain Stimulation on Prepulse Inhibition in Obsessive Compulsive Disorder. Transl Psych Nov 10;5:e675.

Müller, U. J., Truebner, K., Schiltz, K., Kuhn, J., Mawrin, C., Dobrowolny, H., Bernstein, H. G., Bogerts, B., Steiner, J. (2015) Postmortem volumetric analysis of the nucleus accumbens in male heroin addicts: implications for deep brain stimulation. Eur Arch Psychiatry Clin Neurosci. 265, 647-653.

Lewis, C. J., Maier, F., Horstkötter, N., Eggers, C., Visser-Vandewalle, V., Moro, E., Zurowski, M., Kuhn, J., Woopen, C., Timmermann, L. (2015) The impact of subthalamic deep brain stimulation on caregivers of Parkinson's disease patients: an exploratory study. J Neurol. 262(2), 337-345.

2014

Visser-Vandewalle, V., Huys, D., Neuner, I., Zrinzo, L., Okun, M. S., & Kuhn, J. (2014). Deep brain stimulation for Tourette syndrome: The current state of the field. Journal of Obsessive-Compulsive and Related Disorders, 3(4), 401-406.

Diehl-Schmid, J., Onur, O. A., Kuhn, J., Gruppe, T., & Drzezga, A. (2014). Imaging frontotemporal lobar degeneration. Current neurology and neuroscience reports, 14(10), 1-11.

Kohl, S., Schönherr, D. M., Luigjes, J., Denys, D., Mueller, U. J., Lenartz, D., Visser-Vandewalle, V., & Kuhn, J. (2014). Deep brain stimulation for treatment-refractory obsessive compulsive disorder: a systematic review. BMC psychiatry, 14(1), 214.

Müller, U. J., Bogerts, B., Voges, J., Galazky, I., Kohl, S., Heinze, H. J., Kuhn, J., & Steiner, J. (2014). Deep brain stimulation in psychiatry: ethical aspects. Psychiatrische Praxis, 41(S 01), S38-S43.

Schüller, T., Huys, D., Blum, M.,  Lenartz, D., Shubina, E., Visser-Vandewalle, V., Kuhn, J (2014). Deep Brain Stimulation in Tourette Syndrome. Klinische Neurophysiologie, 45(02), 106-112.

Lewis, C. J., Maier, F., Eggers, C., Pelzer, E. A., Maarouf, M., Moro, E., Moro, E., Zurowski, M., Kuhn, J., Woopen, C., & Timmermann, L. (2014). Parkinson's disease patients with subthalamic stimulation and carers judge quality of life differently. Parkinsonism & related disorders, 20(5), 514-519.

Maier, F., Merkl, J., Ellereit, A. L., Lewis, C. J., Eggers, C., Pedrosa, D. J., Kalbe, E., Kuhn, J. Meyer, T.D., Zurowski, M., & Timmermann, L. (2014). Hypomania and mania related to dopamine replacement therapy in Parkinson's disease. Parkinsonism & related disorders, 20(4), 421-427.

Kohl, S., Wolters, C., Gruendler, T. O., Vogeley, K., Klosterkötter, J., & Kuhn, J. (2014). Prepulse inhibition of the acoustic startle reflex in high functioning autism. PloS one, 9(3): e92372.

Bartsch, C., & Kuhn, J. (2014). Tiefe Hirnstimulation für Sucht, Anorexie, und Zwang. Rationale, klinische Ergebnisse und ethische Implikationen [Deep brain stimulation for addiction, anorexia and compulsion. Rationale, clinical results and ethical implications]. Der Nervenarzt, 85(2), 162-168.

Kuhn, J., Möller, M., Treppmann, J. F., Bartsch, C., Lenartz, D., Gruendler, T. O., Maarouf, M., Brosig, A., Barnikol, U.B., Klosterkötter, J., & Sturm, V. (2014). Deep brain stimulation of the nucleus accumbens and its usefulness in severe opioid addiction. Molecular psychiatry, 19(2), 145.

2013

Ackermans, L., Kuhn, J., Neuner, I., Temel, Y., & Visser-Vandewalle, V. (2013). Surgery for Tourette syndrome. World Neurosurgery, 80(3-4), S29.e15–22. doi.org/10.1016/j.wneu.2012.06.017

Hardenacke, K., Kuhn, J., Lenartz, D., Maarouf, M., Mai, J. K., Bartsch, C., … Sturm, V. (2013). Stimulate or degenerate: deep brain stimulation of the nucleus basalis Meynert in Alzheimer dementia. World Neurosurgery, 80(3-4), S27.e35–43. doi.org/10.1016/j.wneu.2012.12.005

Hardenacke, K., Shubina, E., Bührle, C. P., Zapf, A., Lenartz, D., Klosterkötter, J., … Kuhn, J. (2013). Deep brain stimulation as a tool for improving cognitive functioning in Alzheimer’s dementia: a systematic review. Frontiers in Psychiatry, 4.

Kohl, S., Heekeren, K., Klosterkötter, J., & Kuhn, J. (2013). Prepulse inhibition in psychiatric disorders--apart from schizophrenia. Journal of Psychiatric Research, 47(4), 445–52. doi.org/10.1016/j.jpsychires.2012.11.018

Kuhn, J., Bührle, C. P., Lenartz, D., & Sturm, V. (2013). Deep brain stimulation in addiction due to psychoactive substance use. Handbook of Clinical Neurology, 116, 259–69. doi.org/10.1016/B978-0-444-53497-2.00021-8

Muller, U. J., Voges, J., Steiner, J., Galazky, I., Heinze, H. J., Moller, M., … Kuhn, J. (2013). Deep brain stimulation of the nucleus accumbens for the treatment of addiction. Ann N Y Acad Sci, 1282, 119–128. doi.org/10.1111/j.1749-6632.2012.06834.x

Witt, K., Kuhn, J., Timmermann, L., Zurowski, M., & Woopen, C. (2013). Deep Brain Stimulation and the Search for Identity. Neuroethics, 6, 499–511. http://doi.org/10.1007/s12152-011-9100-1

2012

Huys, D., Hardenacke, K., Poppe, P., Bartsch, C., Baskin, B., Kuhn, J. (2012). Update on the role of antipsychotics in the treatment of Tourette syndrome. Neuropsychiatric Disease and Treatment, 8, 95-104.

Huys, D., Möller, M., Kim, E.H., Hardenacke, K., Huff, W., Klosterkötter, J., Timmermann, L., Woopen, C., Kuhn, J. (2012). Die tiefe Hirnstimulation bei psychiatrischen Erkrankungen. Der Nervenarzt, 83(9), 1156-1168.

Kohl, S., Heekeren, K., Klosterkötter, J., Kuhn, J. (2012). Prepulse inhibition in psychiatric disorders – apart from schizophrenia. Journal of Psychiatric Research, in revision.

Kuhn, J., Gruendler, T.O., Klosterkötter, J., Bartsch, C. (2012). Stimulating the addictive brain. Frontiers in Human Neuroscience, 6, 220.

Kuhn, J., Janouschek, H., Raptis, M., Rex, S., Lenartz, D., Neuner, I., Mottaghy, F.M., Schneider, F., Schaefer, W.M., Sturm, V., Gründer, G., Vernaleken, I. (2012). In vivo evidence of deep brain stimulation-induced dopaminergic modulation in Tourette's syndrome. Biological Psychiatry, 71(5), e11-13.

Lehnhardt, F.G., Konkol, C., Kuhn, J. (2012). Anwendung der EKT bei pharmakoresistenter Schizophrenie. Fortschritte der Neurologie - Psychiatrie, 80(9), 501-511.

Schilbach, L., Weiss, P.H., Kuhn, J., Timmermann, L., Klosterkötter, J., Huff, W. (2012). Pharmacological treatment of deep brain stimulation-induced hypomania leads to clinical remission while preserving motor benefits. Neurocase, 18(2), 152-159.

Witt, K., Kuhn, J., Timmermann, L., Woopen, C. (2012). Tiefe Hirnstimulation und personale Identität: Was sollten wir messen? Nervenheilkunde 2012; 31(4), 221-225.

Woopen, C., Timmermann, L., Kuhn, J. (2012). An Ethical Framework for Outcome Assessment in Psychiatric DBS. AJOB Neuroscience 3 (1), 50-55.

2011

Huys, D., Möller, M. V., Kim, E. H., Hardenacke, K., Huff, W., Klosterkötter, J., et al. (2011). Die tiefe Hirnstimulation bei psychiatrischen Erkrankungen. Der Nervenarzt, 1-12.

Kuhn, J., Gründler, T. O. J., Bauer, R., Huff, W., Fischer, A. G., Lenartz, D., et al. (2011). Successful deep brain stimulation of the nucleus accumbens in severe alcohol dependence is associated with changed performance monitoring. Addiction Biology, 1-4.

Kuhn, J., Möller, M., Müller, U. L. F., Bogerts, B., Mann, K., & Gründler, T. O. J. (2011). Deep Brain Stimulation For The Treatment Of Addiction. Addiction, 106(8), 1536-1537.

Skuban, T., Hardenacke, K., Woopen, C., & Kuhn, J. (2011). Informed Consent in Deep Brain Stimulation - Ethical Considerations in a Stress Field of Pride and Prejudice. Frontiers in Integrative Neuroscience, 5, 1-2.

Witt, K., Kuhn, J., Timmermann, L., Zurowski, M., & Woopen, C. (2011). Deep Brain Stimulation and the Search for Identity. Neuroethics, 1-13.

2010

Huff, W., Lenartz, D., Schormann, M., Lee, S. H., Kuhn, J., Koulousakis, A., et al. (2010). Unilateral deep brain stimulation of the nucleus accumbens in patients with treatment-resistant obsessive-compulsive disorder: Outcomes after one year. Clinical Neurology and Neurosurgery, 112(2), 137-143.

Kuhn, J., Grundler, T. O., Lenartz, D., Sturm, V., Klosterkötter, J., & Huff, W. (2010). Deep brain stimulation for psychiatric disorders. Deutsches Ärzteblatt international, 107(7), 105-113.

Kuhn, J., & Huff, W. (2010). Will deep-brain stimulation be as successful in major depression as it has been in Parkinson’s disease? Expert Review of Neurotherapeutics, 10(9), 1363-1365.

2009

Freund, H. J., Kuhn, J., Lenartz, D., Mai, J. K., Schnell, T., Klosterkötter, J., et al. (2009). Cognitive Functions in a Patient With Parkinson-Dementia Syndrome Undergoing Deep Brain Stimulation. Archives of Neurology, 66(6), 781-785.

Kuhn, J., Bauer, R., Pohl, S., Lenartz, D., Huff, W., Kim, E. H., et al. (2009). Observations on Unaided Smoking Cessation after Deep Brain Stimulation of the Nucleus Accumbens. European Addiction Research, 15(4), 196-201.

Kuhn, J., Gaebel, W., Klosterkötter, J., & Woopen, C. (2009). Deep brain stimulation as a new therapeutic approach in therapy-resistant mental disorders: ethical aspects of investigational treatment. European Archives of Psychiatry and Clinical Neuroscience, 259, 135-141.

Vernaleken, I., Kuhn, J., Lenartz, D., Raptis, M., Huff, W., Janouschek, H., et al. (2009). Bithalamical Deep Brain Stimulation in Tourette Syndrome Is Associated with Reduction in Dopaminergic Transmission. Biological Psychiatry, 66(10), e15-e17.

2008

Bauer, R., Pohl, S., Klosterkötter, J., & Kuhn, J. (2008). Abhängigkeitserkrankungen im Kontext der Tiefen Hirnstimulation - eine literaturgestützte systematische Auswertung. Fortschritte der Neurologie - Psychiatrie, 76(07), 396-401.

Kuhn, J., Lenartz, D., Huff, W., Mai, J. K., Koulousakis, A., Maarouf, M., et al. (2008). Transient Manic-like Episode Following Bilateral Deep Brain Stimulation of the Nucleus Accumbens and the Internal Capsule in a Patient With Tourette Syndrome. Neuromodulation, 11(2), 128-131.

Kuhn, J., Lenartz, D., Mai, J. K., Huff, W., Klosterkötter, J., & Sturm, V. (2008). Disappearance of self-aggressive behavior in a brain-injured patient after deep brain stimulation of the hypothalamus: technical case report. Neurosurgery, 62(5), E1182.

2007

Kuhn, J., Huff, W., Lee, S. H., Lenartz, D., Sturm, V., & Klosterkötter, J. (2007). Tiefenhirnstimulation bei psychiatrischen Erkrankungen. Fortschritte der Neurologie - Psychiatrie, 75, 447-457.

Kuhn, J., Lenartz, D., Huff, W., Lee, S., Koulousakis, A., Klosterkötter, J., et al. (2007). Remission of alcohol dependency following deep brain stimulation of the nucleus accumbens: Valuable therapeutic implications? Journal of Neurology, Neurosurgery & Psychiatry, 78(10), 1152-1153.

Kuhn, J., Lenartz, D., Mai, J., Huff, W., Lee, S. H., Koulousakis, A., et al. (2007). Deep brain stimulation of the nucleus accumbens and the internal capsule in therapeutically refractory Tourette-syndrome. Journal of Neurology, 254(7), 963-965.

Das Team

Prof. Jens Kuhn
Dr. Sina Kohl
Priv.-Doz. Dr. Daniel Huys
Dr. Juan Carlos Baldermann
Laura Wehmeyer, M.Sc.
Annika Sauter, MSc (Kooperation Humanwissenschaftliche Fakultät, Universität zu Köln)

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